4040 Pike Lane
94520 Concord
USA

Phone: +1 800 7999499
Fax: +1 925 6038080

http://www.biocare.net

customerservice@biocare.net

Company Figures
Year of foundation 1997
Area of business Electronical Equipment / Medical Technology

Diagnostics

Company Profile

Biocare Medical LLC
Biocare Medical is a unique manufacturer and supplier of immunohistochemical and histopathology products, monoclonal and polyclonal antibodies, and automated staining equipment. We are continually researching the most innovative and cost-effective diagnostic solutions and state-of-the-art equipment. Biocare Medical now offers the “Double Vision” line of double and multiple staining antibodies as well as polymer detection (patent pending).

Biocare Medical’s core strength rests on our unsurpassed team of experts in the market of special stains and immunohistochemistry. Thus, it is our mission to develop and sell products in both arenas, providing a continuous flow of novel products and relentlessly improving upon what we have already launched. This has been and will continue to be accomplished by researching and developing our own proprietary line of products, as well as licensing state-of-the-art products from other companies or co-distributing with them.

The future holds great promise for Biocare Medical and we are poised to make a positive impact on immunohistochemistry staining and special stains for years to come.

Product Information
03.03.11 Monoclonal antibodies for cell surface antigens
COX-2 (Rabbit monoclonal) 02.10.2008

Cyclooxygenase (COX-2) is an inducible enzyme involved in the production of prostaglandins in inflammatory processes. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX-2 is therefore of interest in studying immune response regulation. COX-2 is induced by a wide variety of stimuli and was initially identified as immediate-early growth response gene. There is now increasing evidence that a constitutive expression of COX-2 plays a role in development and progression of malignant epithelial tumors. In studies, COX-2 positivity retained independent roles in predicting a poor chance of response to treatment. COX-2 positive patients had a shorter overall survival rate than COX-2 negative patients.

Progesterone Receptor (Rabbit monoclonal) 02.10.2008

Clone SP2 has been established to work in formalin-fixed, paraffin-embedded tissues. The presence of PR in breast tumors indicates an increased likelihood of response to anti-estrogen (tamoxifen) therapy. Staining patterns observed include: ER+ and PR+, ER+ and PR-, ER- and PR+, and ER- and PR-. The SP2 clone is a high affinity rabbit monoclonal. An in-house study showed that SP2 clone had a much higher affinity as compared to mouse monoclonals for the progesterone receptor. Studies have also shown that the SP2 clone provides supplementary evidence to ER in predicting survival. Excellent results can be achieved with antigen retrieval at lower temperatures such as 80 or 95 degrees Celsius. The robustness of SP2 is further proved by the fact that in some instances staining can be obtained even without antigen retrieval. Thus, SP2 may prove of greater value than ER as a prognostic indicator in human breast cancer.

Vimentin (Rabbit monoclonal) 02.10.2008

This rabbit monoclonal Vimentin recognizes a 57-60 kDa protein, which is identified as vimentin. It shows no cross-reactivity with other closely related intermediate filament proteins such as desmin and GFAP. Vimentin is the main intermediate filament protein in mesenchymal cells, and therefore is of value in the differential diagnosis of undifferentiated neoplasms including melanoma and sarcoma.